AF-353 hydrochloride
This orally bioavailable, brain-penetrant P2X3/P2X2/3 receptor antagonist exhibits potent nanomolar activity in vitro, blocking agonist-evoked calcium flux and currents. Its favorable pharmacokinetic profile supports its use in research on chronic cough, neuropathic pain, and related neurological disorders in both in vitro and in vivo models.
Product Specifications
CAS Number
927887-18-1
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
O (C1=C (C (C) C) C=C (OC) C (I) =C1) C=2C (N) =NC (N) =NC2.Cl
Molecular Formula
C14H17IN4O2?HCl
Molecular Weight
436.68
Storage Conditions
-20°C
Notes
For research use only.
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