Vadadustat
Vadadustat is an orally active, titratable small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) . It is used in research to study anemia treatment mechanisms, demonstrating efficacy in both cellular assays and animal models of renal anemia.
Product Specifications
CAS Number
1000025-07-9
Product Name Alternative
Disease, chronic, anemia, AKB 6548, AKB6548, AKB-6548, inhibit, kidney, nondialysis-dependent, HIF/HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF, HIF-PH, HIF/HIFProlylHydroxylase, HIFs, HIFProlylHydroxylase, Inhibitor, Hypoxia-inducible factors, Erythropoiesis-stimulating, PG1016548, PG-1016548, PG 1016548, Vadadustat
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research, Pharmacology & Drug Discovery
Purity
99.02% (May vary between batches)
Solubility
DMSO:100 mg/mL (326.05 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.04 mM)
Smiles
OC (=O) CNC (=O) c1ncc (cc1O) -c1cccc (Cl) c1
Molecular Formula
C14H11ClN2O4
Molecular Weight
306.7
Storage Conditions
-20°C
Notes
For research use only.
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