Tertiapin (reduced)

Tertiapin (reduced) is a kind of synthesis of melittin, its Cys3-Cys14 and Cys5-Cys18 between containing a disulfide bond. Tertiapin (reduced) is a kind of inward rectifier potassium channels blockers, can block the activity of calcium activates large conductance potassium channels. Tertiapin (reduced) can be used for research in diseases such as rheumatoid arthritis and multiple sclerosis[1].

Product Specifications

CAS Number

[58694-52-3]

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tertiapin-reduced.html

Smiles

NCCCC[C@@H](C(N)=O)NC([C@H](CCCCN)NC(CNC([C@H](CS)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CS)NC([C@H](CCSC)NC([C@H](CC1=CN=CN1)NC([C@H]2N(CCC2)C([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CS)NC([C@H](CC(N)=O)NC([C@H](CS)NC([C@H](CC(C)C)NC([C@@H](N)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O

Molecular Formula

C106H180N34O23S5

Molecular Weight

2459.10

References & Citations

[1]Kitamura H, et al. Tertiapin potently and selectively blocks muscarinic K+ channels in rabbit cardiac myocytes[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 293 (1) : 196-205.