AF615
AF615 is a potent small-molecule disruptor of the CDT1/Geminin interaction, exhibiting IC50 values of 0.313 μM. This compound demonstrates selective genotoxic effects in cancer cells, including DNA synthesis inhibition, cell cycle arrest, and reduced viability. Binding studies reveal differential affinity for protein variants (Ki = 0.37 μM for Geminin-tCDT1 vs 0.75 μM for Geminin-miniCDT1) .
Product Specifications
CAS Number
122510-61-6
Purity
>98%
Smiles
O1CCN (C (=S) NNC (C2=CN=CC=N2) =O) CC1
Molecular Formula
C10H13N5O2S
Molecular Weight
267.307
Notes
For research use only.
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