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CXCR6 inhibitor 81

CXCR6 inhibitor 81 is a potent (EC50=40 nM) and selective orally bioavailable small molecule antagonist of human CXCR6 receptor; Compound 81 displays >10-fold improvement in potency in both the β-arrestin and cAMP assays (IC50 =40 and 540 nM, respectively) compared to ML339. CXCR6 inhibitor 81 inhibits migration of SK-HEP-1 hepatoma cells in a dose dependent manner. Compound 81 has promising oral DMPK data, significantly decreases tumor growth in a 30-day mouse xenograft model of HCC.

Product Specifications

CAS Number

2579689-85-1

Field of Research

Immunology & Inflammation; Pharmacology & Drug Discovery

Purity

>98%

Smiles

C (NC1CC2N (CC3=NC4=C (C (F) (F) F) C=CC=C4S3) C (CCC2) C1) (=O) C1=CC (OC) =C (OC) C (OC) =C1

Molecular Formula

C27H30F3N3O4S

Molecular Weight

549.605016231537

Notes

For research use only.

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