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UC-764865

UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.

Product Specifications

CAS Number

2566480-63-3

Purity

>98%

Smiles

C (C1=CC=C (OC) C=C1) (=O) /C=C\SC1NC2=CC (C) =CC=C2N=1

Molecular Formula

C18H16N2O2S

Molecular Weight

324.396842956543

Notes

For research use only.

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