UC-764865
UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.
Product Specifications
CAS Number
2566480-63-3
Purity
>98%
Smiles
C (C1=CC=C (OC) C=C1) (=O) /C=C\SC1NC2=CC (C) =CC=C2N=1
Molecular Formula
C18H16N2O2S
Molecular Weight
324.396842956543
Notes
For research use only.
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