PEG3-bis (phosphonic acid diethyl ester)

This polyethylene glycol (PEG) -based bisphosphonate ester linker is engineered for constructing proteolysis targeting chimeras (PROTACs) . It serves as a critical spacer to connect E3 ligase ligands with target protein binders, facilitating the development of degraders for both in vitro and in vivo research applications.