CL2A
CL2A is a pH-sensitive, cleavable linker featuring a PEG8 spacer and a self-immolative PABC system, connected via a triazole moiety. It enables antibody-drug conjugation through a disulfide bond and is designed to release potent payloads with a bystander effect, as utilized in the ADC labetuzumab govitecan for targeted cancer therapy research.
Product Specifications
CAS Number
1846605-04-6
Field of Research
Pharmacology & Drug Discovery
Smiles
C (C1CCC (C (NCC2=CN (CCOCCOCCOCCOCCOCCOCCOCCOCCNC (COCC (N[C@H] (C (NC3=CC=C (COC (O) =O) C=C3) =O) CCCCN) =O) =O) N=N2) =O) CC1) N4C (=O) C=CC4=O
Molecular Formula
C51H79N9O18
Molecular Weight
1106.22
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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