(Rac) -PF-4136309 (1341224-83-6 Free base)
PF-4136309 (INCB8761) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM against the human receptor. It has been widely used in preclinical research to investigate the role of CCR2 in inflammatory diseases and cancer metastasis, demonstrating efficacy in both in vitro assays and in vivo animal models.
Product Specifications
CAS Number
857679-55-1
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (NC1=NC=C2C=CC (=CC2=C1) C=3C=NN (C3) C) C=4C=CN=C (C4) N5CCN (C) CC5
Molecular Formula
C29H31F3N6O3
Molecular Weight
568.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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