KP-457
KP-457 is a selective small-molecule inhibitor targeting ADAM17/TACE, effectively suppressing the enzymatic release of soluble TNFα (sTNF) . This compound is a valuable research tool for investigating TNF-mediated pathways in inflammatory and oncological disease models, both in cellular and animal studies.
Product Specifications
CAS Number
1365803-52-6
Product Name Alternative
ADAM17, KP 457, KP457, KP-457, TNF‐α‐converting enzyme
Field of Research
Protein Biochemistry
Purity
98.33% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.32 mM) ; DMSO:100 mg/mL (208.09 mM)
Smiles
C (CS (=O) (=O) C1=CC=C (OCC#CC) C=C1) (N (C=O) O) C2=CC=C (CNS (C) (=O) =O) C=C2
Molecular Formula
C21H24N2O7S2
Molecular Weight
480.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
FAB23501N-100UG 100 µg
Human CCRL2/CRAM-A/B Alexa Fluor 700 Antibody
Sign In for Pricing
View Details 
GTR15234310 1 Vial
Lentiviral mouse Slc47a2 shRNA (UAS) - Lentiviral mouse Slc47a2 shRNA (UAS, GFP) plasmid
Sign In for Pricing
View Details 
MBS1242817-01 0.02 mg (E-Coli)
Recombinant Herpetosiphon aurantiacus Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
Sign In for Pricing
View Details MBS1242817-02 0.02 mg (Yeast)
Recombinant Herpetosiphon aurantiacus Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
Sign In for Pricing
View Details MBS1242817-03 0.1 mg (E-Coli)
Recombinant Herpetosiphon aurantiacus Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
Sign In for Pricing
View Details MBS1242817-04 0.1 mg (Yeast)
Recombinant Herpetosiphon aurantiacus Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
Sign In for Pricing
View Details