KP-457
KP-457 is a selective small-molecule inhibitor targeting ADAM17/TACE, effectively suppressing the enzymatic release of soluble TNFα (sTNF) . This compound is a valuable research tool for investigating TNF-mediated pathways in inflammatory and oncological disease models, both in cellular and animal studies.
Product Specifications
CAS Number
1365803-52-6
Product Name Alternative
ADAM17, KP 457, KP457, KP-457, TNF‐α‐converting enzyme
Field of Research
Protein Biochemistry
Purity
98.33% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.32 mM) ; DMSO:100 mg/mL (208.09 mM)
Smiles
C (CS (=O) (=O) C1=CC=C (OCC#CC) C=C1) (N (C=O) O) C2=CC=C (CNS (C) (=O) =O) C=C2
Molecular Formula
C21H24N2O7S2
Molecular Weight
480.56
Storage Conditions
-20°C
Notes
For research use only.
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