Val-Ala-PAB-MMAE
Val-Ala-PAB-MMAE is a cathepsin B-cleavable ADC linker-payload conjugate. Upon intracellular cleavage, it releases the cytotoxic agent MMAE to disrupt microtubule assembly, inducing apoptosis in targeted cells. This construct is widely used in ADC research for evaluating antitumor efficacy in both in vitro and in vivo models.
Product Specifications
CAS Number
1912408-92-4
Product Name Alternative
DrugLinkerConjugatesforADC, DrugLinker Conjugates for ADC
Field of Research
Signal Transduction
Purity
99.02% (May vary between batches)
Solubility
DMSO:80 mg/mL (77.12 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (3.18 mM)
Smiles
[C@H] ([C@H] (C (N[C@@H] ([C@@H] (O) C1=CC=CC=C1) C) =O) C) (OC) [C@]2 (N (C (C[C@H] ([C@@H] (N (C ([C@@H] (NC ([C@@H] (N (C (OCC3=CC=C (NC ([C@@H] (NC ([C@H] (C (C) C) N) =O) C) =O) C=C3) =O) C) C (C) C) =O) [C@@H] (C) C) =O) C) [C@H] (CC) C) OC) =O) CCC2) [H]
Molecular Formula
C55H88N8O11
Molecular Weight
1037.33
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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