Mal-PEG2-Gly-Gly-Phe-Gly-Exatecan
This maleimide-PEG2-tetrapeptide linker-drug conjugate incorporates the topoisomerase I inhibitor Exatecan, enabling the synthesis of antibody-drug conjugates (ADCs) for targeted cancer therapy research. It is applied in both in vitro cytotoxicity assays and in vivo preclinical studies to evaluate ADC efficacy and payload delivery.
Product Specifications
CAS Number
1599439-54-9
Field of Research
Metabolism Research; Pharmacology & Drug Discovery, Molecular Biology
Smiles
N (C (CCCNC (CNC ([C@H] (CC1=CC=CC=C1) NC (CNC (CNC (CCOCCOCCNC (CCN2C (=O) C=CC2=O) =O) =O) =O) =O) =O) =O) =O) [C@@H]3C4=C5C (C=6N (C5) C (=O) C7=C (C6) [C@] (CC) (O) C (=O) OC7) =NC=8C4=C (CC3) C (C) =C (F) C8
Molecular Formula
C57H65FN10O15
Molecular Weight
1149.18
Storage Conditions
-20°C
Notes
For research use only.
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