CXCR3 antagonist 1

CXCR3 antagonist 1 (compound 6c) is a selective and non-cytotoxic CXCR3 antagonist (IC50=0.06 µM) . CXCR3 antagonist 1 has potential in researching inflammatory diseases (including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes) [1].

Product Specifications

CAS Number

[870998-13-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cxcr3-antagonist-1.html

Purity

98.6

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(Cl)=CC=C1)NC2=CC(C(NCCC3=CC=C(C=C3Cl)Cl)=O)=CC=C2N4CCN(CCC4)C(NCC)=O

Molecular Formula

C30H32Cl3N5O3

Molecular Weight

616.97

Precautions

H302, H315, H319, H335

References & Citations

[1]Cole A G, et al. Identification and initial evaluation of 4-N-aryl-[1, 4] diazepane ureas as potent CXCR3 antagonists. Bioorganic Med. Chem Lett. 2006 Jan;16 (1) :200-203.