2-Ethoxybenzamide

2-Ethoxybenzamide (Ethenzamide) is a nonsteroidal anti-inflammatory agent that shows analgesic and antipyretic effects. 2-Ethoxybenzamide induces melanin synthesis via cAMP response element-binding protein (CREB) phosphorylation. 2-Ethoxybenzamide can be used in the research of hypopigmentation and inflammation-related diseases[1][2].

Product Specifications

CAS Number

[938-73-8]

Product Name Alternative

Ethenzamide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PERK; Reactive Oxygen Species (ROS) ; Tyrosinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-Ethoxybenzamide.html

Purity

99.82

Solubility

DMSO : ≥ 47 mg/mL

Smiles

O=C(N)C1=CC=CC=C1OCC

Molecular Formula

C9H11NO2

Molecular Weight

165.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Srinivasulu Aitipamula, et al. Pharmaceutical cocrystals of ethenzamide: structural, solubility and dissolution studies. CrystEngComm, 2012,14, 8515-8524.|[2]Kazuomi Sato, et al. 2-Ethoxybenzamide stimulates melanin synthesis in B16F1 melanoma cells via the CREB signaling pathway. Mol Cell Biochem. 2016 Dec;423 (1-2) :39-52.