α-Factor Mating Pheromone, yeast TFA

The α-Factor Mating Pheromone is a 13-amino acid peptide secreted by yeast α-cells that binds the G-protein-coupled receptor Ste2p. It is widely used in vitro and in vivo to study yeast mating signaling, cell cycle arrest, and GPCR function in model systems like Saccharomyces cerevisiae.