Gap 27
Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment[1][2].
Product Specifications
CAS Number
198284-64-9
UNSPSC
12352209
Target
Connexin; Gap Junction Protein
Type
Peptides
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Gap_27.html
Purity
99.90
Solubility
DMSO : 22.22 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl) |H2O : ≥ 33.33 mg/mL
Smiles
OC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C60H101N15O17
Molecular Weight
1304.53
References & Citations
[1]Ilvesaro J, et al. Connexin-mimetic peptide Gap 27 decreases osteoclastic activity. BMC Musculoskelet Disord. 2001;2:10.|[2]Edwards G, et al. Role of gap junctions in the responses to EDHF in rat and guinea-pig small arteries. Br J Pharmacol. 1999 Dec;128 (8) :1788-94.|[3]Chaytor AT, e t al. Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J Physiol. 1998 Apr 15;508 (Pt 2) :561-73.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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