Gap 27
Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment[1][2].
Product Specifications
CAS Number
198284-64-9
UNSPSC
12352209
Target
Connexin; Gap Junction Protein
Type
Peptides
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Gap_27.html
Purity
99.90
Solubility
DMSO : 22.22 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl) |H2O : ≥ 33.33 mg/mL
Smiles
OC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C60H101N15O17
Molecular Weight
1304.53
References & Citations
[1]Ilvesaro J, et al. Connexin-mimetic peptide Gap 27 decreases osteoclastic activity. BMC Musculoskelet Disord. 2001;2:10.|[2]Edwards G, et al. Role of gap junctions in the responses to EDHF in rat and guinea-pig small arteries. Br J Pharmacol. 1999 Dec;128 (8) :1788-94.|[3]Chaytor AT, e t al. Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J Physiol. 1998 Apr 15;508 (Pt 2) :561-73.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR10395432 96 Well
Chicken CAAX prenyl protease 2 (RCE1) ELISA kit
Sign In for Pricing
View Details 