PROTAC BTK Degrader-6
PROTAC BTK Degrader-6 (Compound 15) is a potent degrader (DC50 = 3.18 nM) that demonstrates anti-inflammatory activity through NF-κB pathway inhibition and reduction of IL-1β and IL-6. This molecule is a valuable chemical tool for investigating BTK-related immunology and inflammation in both cellular and animal models.
Product Specifications
CAS Number
2767204-39-5
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
NC1=C2C (=NN (C2=NC=N1) C3CCN (C (CN4CCN (CC5CN (C5) C=6C=C7C (=CC6) C (=O) N (C7=O) C8C (=O) NC (=O) CC8) CC4) =O) CC3) C9=CC=C (OC%10=CC=CC=C%10) C=C9
Molecular Formula
C45H47N11O6
Molecular Weight
837.92
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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