AD4

AD4 is a potent artemisinin-based PROTAC that induces targeted degradation of PCLAF with an IC50 of 0.6 nM in RS4;11 cells. This action activates the p21/Rb pathway, demonstrating antitumor effects in vitro and extending survival in a mouse xenograft model, supporting its study in oncology and targeted protein degradation research.

Product Specifications

CAS Number

2918262-09-4

Field of Research

Pharmacology & Drug Discovery

Smiles

C[C@@H]1[C@]2 ([C@]34[C@@] (O[C@] (C) (OO3) CC[C@]4 ([C@H] (C) CC2) [H]) (O[C@@H]1OCCN (CCO[C@H]5O[C@]6 ([C@]78[C@] ([C@H]5C) (CC[C@@H] (C) [C@@]7 (CC[C@] (C) (O6) OO8) [H]) [H]) [H]) C (CCCCCCCNC9=C%10C (C (=O) N (C%10=O) C%11C (=O) NC (=O) CC%11) =CC=C9) =O) [H]) [H]