AD4
AD4 is a potent artemisinin-based PROTAC that induces targeted degradation of PCLAF with an IC50 of 0.6 nM in RS4;11 cells. This action activates the p21/Rb pathway, demonstrating antitumor effects in vitro and extending survival in a mouse xenograft model, supporting its study in oncology and targeted protein degradation research.
Product Specifications
CAS Number
2918262-09-4
Field of Research
Pharmacology & Drug Discovery
Smiles
C[C@@H]1[C@]2 ([C@]34[C@@] (O[C@] (C) (OO3) CC[C@]4 ([C@H] (C) CC2) [H]) (O[C@@H]1OCCN (CCO[C@H]5O[C@]6 ([C@]78[C@] ([C@H]5C) (CC[C@@H] (C) [C@@]7 (CC[C@] (C) (O6) OO8) [H]) [H]) [H]) C (CCCCCCCNC9=C%10C (C (=O) N (C%10=O) C%11C (=O) NC (=O) CC%11) =CC=C9) =O) [H]) [H]
Molecular Formula
C55H78N4O15
Molecular Weight
1035.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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