AD186

AD186 is a potent and selective sigma-1 receptor (S1R) agonist with high affinity (Ki = 2.7 nM) and 10-fold selectivity over the sigma-2 receptor. It serves as a valuable pharmacological tool for investigating S1R function in neuropathic pain models, as evidenced by its ability to reverse the antiallodynic effects of BD-1063 in vivo.