CHF5407

CHF5407 is a selective, long-acting and competitive muscarinic M3 receptor antagonist. CHF5407 shows subnanomolar affinities for human muscarinic M1 (hM1), M2 (hM2) and M3 (hM3) receptors. CHF5407 shows a prolonged antibronchospastic activity[1].

Product Specifications

CAS Number

[1004312-94-0]

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1-Azoniabicyclo[2.2.2]octane,_3-[[[_3-fluorophenyl_[_3,4,5-trifluorophenyl_methyl]amino]carbonyl]oxy]-1-[2-oxo-2-_2-thienyl_ethyl]-,_bromide,_3R_-.html

Purity

99.68

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CS1)C[N+]23C[C@@H](C(CC3)CC2)OC(N(C4=CC(F)=CC=C4)CC5=CC(F)=C(F)C(F)=C5)=O.[Br-]

Molecular Formula

C27H25BrF4N2O3S

Molecular Weight

613.46

References & Citations

[1]G Villetti, et al. Bronchodilator activity of (3R) -3-[[[ (3-fluorophenyl) [ (3,4,5-trifluorophenyl) methyl]amino] carbonyl]oxy]-1-[2-oxo-2- (2-thienyl) ethyl]-1-azoniabicyclo[2.2.2]octane bromide (CHF5407), a potent, long-acting, and selective muscarinic M3 receptor antagonist. J Pharmacol Exp Ther. 2010 Dec;335 (3) :622-35.