Pim-1 kinase inhibitor 5

This small molecule Pim-1 kinase inhibitor (Compound 4c) demonstrates potent enzymatic inhibition (IC50 = 0.61 μM) and exhibits cytotoxic activity against a panel of human cancer cell lines, including HepG2, MCF-7, PC3, and HCT-116, with IC50 values from 6.95 to 20.19 μM. It is a useful research tool for studying Pim-1 kinase signaling in oncology and cell proliferation, applicable in both in vitro and in vivo experimental models.