BACE1-IN-13
BACE1-IN-13 (Compound 36) is a potent, orally bioavailable BACE1 inhibitor with IC50 values of 2.9 nM and 1.3 nM in biochemical and cellular (hAβ42) assays, respectively. It demonstrates a sustained reduction of Aβ42 in vivo in mouse and dog models and shows a favorable cardiovascular safety profile, supporting its use in Alzheimer's disease research.
Product Specifications
CAS Number
1397683-26-9
Field of Research
Cell Biology, Neuroscience
Smiles
C[C@]1 (CN2C (C (N) =N1) =CC (C#N) =N2) C3=CC (NC (=O) C=4C=NC (OC) =CN4) =CC=C3F
Molecular Formula
C20H17FN8O2
Molecular Weight
420.4
Storage Conditions
-20°C
Notes
For research use only.
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