PROTAC MEK1 Degrader-1
PROTAC MEK1 Degrader-1 is a bifunctional molecule that recruits MEK1 to the VHL E3 ligase for targeted degradation, thereby inhibiting ERK1/2 phosphorylation. With a pIC50 of 7.0, it demonstrates antiproliferative effects in A375 melanoma cells in vitro, supporting its use in oncology and targeted protein degradation research.
Product Specifications
CAS Number
2671004-41-2
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
N (C1=C (NS (=O) (=O) C2=CC=C (CCC (NCCOCCOCCOCC (N[C@H] (C (=O) N3[C@H] (C (N[C@@H] (C) C4=CC=C (C=C4) C=5SC=NC5C) =O) C[C@@H] (O) C3) C (C) (C) C) =O) =O) C=C2) C=C (C) C (=O) N1C) C6=C (F) C=C (I) C=C6
Molecular Formula
C53H66FIN8O11S2
Molecular Weight
1201.17
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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