PROTAC EGFR degrader 8
PROTAC EGFR degrader 8 (T-184) is a potent and selective degrader of EGFR, demonstrating a DC50 of 15.56 nM in HCC827 cells and anti-proliferative activity in NSCLC lines like H1975 and PC-9. It serves as a valuable chemical tool for investigating targeted protein degradation in non-small cell lung cancer research, both in vitro and in vivo.
Product Specifications
CAS Number
2925923-46-0
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O (C) C=1C=C (C=CC1NC=2N=C (NC3=C (C (NC) =O) C=CC=C3) C (Cl) =CN2) N4CCN (C (CN5CCN (CC5) C6=CC=C (NC7C (=O) NC (=O) CC7) C=C6) =O) CC4
Molecular Formula
C40H46ClN11O5
Molecular Weight
796.32
Storage Conditions
-20°C
Notes
For research use only.
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