(R) -SKBG-1
(R) -SKBG-1 is a small molecule inhibitor of the RNA-binding protein NONO (EC50 = 1.5 μM in 22Rv1 cells) . It downregulates full-length androgen receptor (AR) and AR-V7 splice variant expression, leading to anti-proliferative effects in prostate cancer cell lines and broad transcriptomic and proteomic alterations.
Product Specifications
CAS Number
2955634-67-8
Product Name Alternative
Androgen Receptor, AndrogenReceptor
Field of Research
Epigenetics & Chromatin, Metabolism Research
Purity
97.15% (May vary between batches)
Solubility
DMSO:80 mg/mL (161.3 mM)
Smiles
S (=O) (=O) (N1[C@@H] (C (NCC2=CC=C (OC) C=C2) =O) CN (C (CCl) =O) CC1) C3=CC=C (OC) C=C3
Molecular Formula
C22H26ClN3O6S
Molecular Weight
495.98
Storage Conditions
-20°C
Notes
For research use only.
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