DQn-1

DQN-1 is a potent antifolate compound with significant antitubercular activity, exhibiting an MIC90 of 0.03 μM against Mycobacterium tuberculosis. It acts as a potent inhibitor of both Mtb and human DHFR enzymes, with IC50 values in the low nanomolar range. This inhibitor is a valuable tool for investigating folate metabolism in tuberculosis research, including in vitro enzyme inhibition and whole-cell antibacterial studies.