PTD10
PTD10 is a potent PROTAC BTK degrader with sub-nanomolar DC50 and KD values, effectively degrading BTK and inhibiting proliferation in B-cell lines like Ramos and JeKo-1. It induces apoptosis via caspase and mitochondrial pathways, making it a valuable tool for studying B-cell malignancies and dysregulation in vitro.
Product Specifications
CAS Number
2642231-19-2
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.12% (May vary between batches)
Smiles
O=C1C=2N (C3=C (C2) CC (C) (C) C3) CCN1C4=C (CO) C (=CC=N4) C=5C=C (NC6=CC=C (C=N6) N7[C@@H] (C) CN (C (CNC8=C9C (C (=O) N (C9=O) C%10C (=O) NC (=O) CC%10) =CC=C8) =O) CC7) C (=O) N (C) C5
Molecular Formula
C49H51N11O8
Molecular Weight
922.99
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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