MC-EVCit-PAB-MMAE
MC-EVCit-PAB-MMAE (Linker-Payload 11) is a cleavable linker-payload complex for constructing antibody-drug conjugates (ADCs) . It releases the potent antimitotic agent MMAE, a tubulin inhibitor, upon cleavage. This payload is widely used in ADC research for targeted cancer therapy, enabling both in vitro cytotoxicity studies and in vivo efficacy evaluations in preclinical models.
Product Specifications
CAS Number
2873452-49-2
Field of Research
Signal Transduction
Smiles
[C@H] ([C@H] (C (N[C@@H] ([C@@H] (O) C1=CC=CC=C1) C) =O) C) (OC) [C@]2 (N (C (C[C@H] ([C@@H] (N (C ([C@@H] (NC ([C@@H] (N (C (OCC3=CC=C (NC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC (CCCCCN4C (=O) C=CC4=O) =O) CCC (O) =O) =O) [C@H] (C) C) =O) CCCNC (N) =O) =O) C=C3) =O) C) C (C) C) =O) [C@@H] (C) C) =O) C) [C@H] (CC) C) OC) =O) CCC2) [H]
Molecular Formula
C73H112N12O18
Molecular Weight
1445.74
Storage Conditions
-20°C
Notes
For research use only.
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