DPP-4-IN-8

DPP-4-IN-8 (compound 27) is a potent, selective DPP4 inhibitor (Ki=0.96 μM) effective in cellular models like Caco-2 and HepG-2. It suppresses DPP4's dipeptidase activity and dose-dependently lowers pro-inflammatory chemokine expression, including TNF-α, IL-6, and IL-1β, supporting research in metabolism and inflammation.