PRMT5-IN-31

PRMT5-IN-31 is a selective PRMT5 inhibitor (IC50: 0.31 μM) that stabilizes hnRNP E1 by occupying the enzyme's substrate binding site. It demonstrates antiproliferative activity in A549 lung cancer cells by inducing apoptosis and inhibiting migration, alongside high metabolic stability, supporting its use in oncology and epigenetics research.