Antibacterial agent 144

Antibacterial Agent 144 (8e) demonstrates potent activity against multidrug-resistant S. aureus by disrupting the cell membrane and inhibiting biofilms. Its efficacy is further enhanced through HSA binding (Kd=13.2 μM) and DNA complexation, which impedes replication. This profile supports its investigation in antimicrobial research for both in vitro and in vivo applications.