MK-8768
MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the metabotropic glutamate receptor 2 (mGluR2) with an IC50 of 9.6 nM. Its excellent brain penetration supports its use in both in vitro binding studies and in vivo models for researching CNS disorders such as anxiety, schizophrenia, and addiction.
Product Specifications
CAS Number
1432729-22-0
Field of Research
Neuroscience
Smiles
C (N) (=O) C=1C=C (C2=C (C=C (CN3C[C@H] (C (F) (F) F) O[C@H] (C) C3) C=C2) N1) C4=CN (C) N=C4
Molecular Formula
C21H22F3N5O2
Molecular Weight
433.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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