A3AR agonist 1

Compound 12 is a potent and selective A3 adenosine receptor agonist (Ki = 25.8 nM) that effectively recruits β-arrestin2 (EC50 = 5.17 nM) . This research compound is utilized in studies of inflammatory diseases, cancer, neuropathic pain, and ischemia, with applications in both in vitro signaling assays and in vivo disease models.