PDE1-IN-5

PDE1-IN-5 (Compound 10c) is a potent and selective PDE1C inhibitor (IC50 = 15 nM) with demonstrated anti-inflammatory activity. It suppresses LPS-induced pro-inflammatory mediators like iNOS, TNF-α, and interleukins. Its efficacy in reducing colitis symptoms in a DSS-induced mouse model highlights its utility for inflammatory disease research, particularly for studying IBD mechanisms.