PARP1-IN-15

PARP1-IN-15 (Compound 6) is a dual inhibitor of PARP1 and tankyrase (TNKS) that induces DNA double-strand breaks and apoptosis. It demonstrates potent anti-tumor activity in both in vitro and in vivo models of triple-negative breast cancer (TNBC), including BRCA1-mutant and wild-type contexts, supporting its use in oncology research.