DprE1-IN-5

DprE1-IN-5 is a potent, stable small molecule inhibitor of the DprE1 enzyme, demonstrating anti-tuberculosis activity with a 4 μM MIC against Mtb H37Rv and efficacy against drug-resistant strains. Its high microsomal stability supports its utility in both in vitro mechanistic studies and in vivo pharmacokinetic research for novel TB therapeutic development.