Thalidomide-Piperazine-PEG1-COOH

Thalidomide-Piperazine-PEG1-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2731007-11-5]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-piperazine-peg1-cooh.html

Purity

99.24

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC=C(N4CCN(CCOCCC(O)=O)CC4)C=C31)=O

Molecular Formula

C22H26N4O7

Molecular Weight

458.46

Precautions

H302, H312, H332

References & Citations

[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-993.