SA-VA
SA-VA is an intracellular self-assembling PROTAC designed for the selective degradation of VEGFR-2 and EphB4. It is activated in situ via a copper-catalyzed click reaction utilizing endogenous tumor copper, inducing S-phase cell cycle arrest and apoptosis in U87 glioblastoma cells for targeted cancer research.
Product Specifications
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C50H53ClF3N11O7S
Molecular Weight
1044.54
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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