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Sirt1/2-IN-2

Sirt1/2-IN-2 (hsa55) is a dual SIRT1/2 inhibitor with IC50 values of 1.8 μM and 2.4 μM, respectively. It increases acetylation of p53 and α-tubulin, inhibits cell proliferation, and induces apoptosis in human leukemia cells in vitro, making it a useful research tool for studying sirtuin biology and cancer.

Product Specifications

CAS Number

670267-73-9

Field of Research

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Smiles

N (S (=O) (=O) C1=CC=CC=C1) C=2C3=C (C (O) =C (SC=4NC=NN4) C2) C=CC=C3

Molecular Formula

C18H14N4O3S2

Molecular Weight

398.46

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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