Sirt1/2-IN-3
Sirt1/2-IN-3 is a dual SIRT1/2 inhibitor (IC50: 1.4 μM and 2.0 μM) that increases acetylation of p53 and α-tubulin, blocking deacetylation. It induces apoptosis and shows antiproliferative activity in human leukemia cell lines in vitro, supporting its use in oncology and epigenetics research.
Product Specifications
CAS Number
301313-42-8
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Smiles
COC1=CC=C (C=C1) S (=O) (=O) NC1=C2C=CC=CC2=C (O) C (Cl) =C1
Molecular Formula
C17H14ClNO4S
Molecular Weight
363.82
Storage Conditions
-20°C
Notes
For research use only.
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