SARS-CoV-2 3CLpro-IN-18

SARS-CoV-2 3CLpro-IN-18 is a covalent inhibitor of the SARS-CoV-2 3CL protease, exhibiting potent enzymatic inhibition (IC50 = 0.478 μM) and antiviral activity in Vero E6 cells (EC50 = 2.499 μM) with low cytotoxicity. This compound is a valuable research tool for studying coronavirus replication and for the development of antiviral therapeutics in both biochemical and cellular assays.