Paluratide
Paluratide (LUNA18) is an orally bioavailable, cell-permeable cyclic peptide that reversibly inhibits KRAS. It functions by blocking the RAS-GEF interaction and reducing ERK and AKT phosphorylation, thereby suppressing the proliferation of KRAS-mutant cancer cells in both in vitro and in vivo research models.
Product Specifications
CAS Number
2676177-63-0
Product Name Alternative
LUNA 18, LUNA18
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
98.70% (May vary between batches)
Solubility
DMSO:80 mg/mL (55.65 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (2.3 mM)
Smiles
O=C1C2 (NC (=O) [C@]3 (N (C (=O) [C@H] (CCC4=CC (F) =C (C (F) (F) F) C (F) =C4) NC (=O) CN (C) C (=O) [C@H] (CC5=CC=C (C) C=C5) N (CC) C (=O) [C@]6 (N (C (=O) [C@H] (C) N (C) C (=O) [C@] ([C@H] (CC) C) (NC (=O) [C@H] (CC (C) C) N (C) C (=O) C[C@@H] (C (N (C) C) =O) N (C) C (=O) [C@@H] (N1C) C7CCCC7) [H]) CC6) [H]) CCC3) [H]) CCCC2
Molecular Formula
C73H105F5N12O12
Molecular Weight
1437.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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