SIRT6-IN-3
SIRT6-IN-3 (8a) is a selective SIRT6 inhibitor (IC50 = 7.49 μM) that suppresses proliferation and induces apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. It synergizes with gemcitabine by inhibiting DNA damage repair, making it a useful chemical probe for studying pancreatic cancer biology in vitro.
Product Specifications
CAS Number
3023471-40-8
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Smiles
[Br-].Cl.BrC=1C=C (NC1Br) C2=NC=CC3=C2N=CN3CCCCCCSC (N (C) C) =[N+] (C) C
Molecular Formula
C21H30Br3ClN6S
Molecular Weight
673.73
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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