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VHL-IN-1

VHL-IN-1 is a potent VHL E3 ligase inhibitor with a 37 nM Kd, effectively stabilizing HIF-1α and augmenting its transcriptional function. This small molecule is a valuable chemical probe for hypoxia research and serves as a foundational component for developing PROTAC degraders in both cellular and animal studies.

Product Specifications

Field of Research

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Pharmacology & Drug Discovery

Molecular Formula

C28H37FN4O4S

Molecular Weight

544.68

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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