BRD4 Inhibitor-10

BRD4 Inhibitor-10 (Compound II-25) is a potent BRD4-BD1 inhibitor with an IC50 of 8 nM. BRD4 Inhibitor-10 can be used to study diseases caused by abnormal or excessive cell proliferation, such as cancer[1].

Product Specifications

CAS Number

[1660117-38-3]

UNSPSC

12352005

Hazard Statement

H302, H319, H332, H372, H400

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brd4-inhibitor-10.html

Purity

99.52

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CN1C(C(C)=CC(C2=NC3=CN=C(C=C3N2[C@H](C4=CC=CC=C4)C)C5CCOCC5)=N1)=O

Molecular Formula

C25H27N5O2

Molecular Weight

429.51

Precautions

H302, H319, H332, H372, H400

References & Citations

[1]Harald Engelhardt, et al. Pyridinones. WO2015022332A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

BRD4

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