CYP51/PD-L1-IN-3

CYP51/PD-L1-IN-3 (L21) is a dual-target quinazoline inhibitor of fungal CYP51 and PD-L1, demonstrating potent in vitro antifungal activity. Its mechanism involves inducing mitochondrial dysfunction, ROS accumulation, and suppression of key inflammatory proteins like NLRP3, leading to fungal apoptosis and cell death. This profile supports its research application in studying fungal pathogenesis and immunomodulation.